Journal of Medical Cases, ISSN 1923-4155 print, 1923-4163 online, Open Access
Article copyright, the authors; Journal compilation copyright, J Med Cases and Elmer Press Inc
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Case Report

Volume 6, Number 8, August 2015, pages 367-372

Subtrochanteric Fracture as First Sign of Metastatic Breast Cancer: Case Presentation

Figures

Figure 1.
Figure 1. Pelvic AP X-ray showing a Seinsheimer IIB pathological bone subtrochanteric fracture.
Figure 2.
Figure 2. 3D CT scan showing a Seinsheimer IIB pathological bone subtrochanteric fracture with secondary dissemination in the trochanteric and femoral neck region.
Figure 3.
Figure 3. Postoperative hip X-ray showing intralesional fixation with a long CMD.
Figure 4.
Figure 4. H&E stain, × 100: a solid group of tumor cells surrounded by areas of bone tissue, connective tissue, a smooth muscle cell and extravased red blood cells, (B).
Figure 5.
Figure 5. H&E stain, × 200 solid group of cohesive tumor cells with moderated pleomorphic nuclei surrounded by RBCs.
Figure 6.
Figure 6. H&E stain, × 400 Glandular lumen revealed in one of the tumor cell nests
Figure 7.
Figure 7. DAB view, hematoxylin counterstain, positive diffuse and intense reaction for CK7 in tumor cells. Anti-CK7 × 200.
Figure 8.
Figure 8. DAB view, hematoxylin counterstain, diffuse and intense reaction for mammaglobin. Anti-mammaglobin, × 200.
Figure 9.
Figure 9. DAB view, hematoxylin counterstain, membrane marking for E-cadherin in tumor cells. Anti-E-cadherin, × 400.
Figure 10.
Figure 10. DAB view, hematoxylin counterstain, diffuse and intense expression of ER in tumor cell. Anti-ER, × 400.
Figure 11.
Figure 11. DAB view, hematoxylin counterstain, focal reactivity for p63 in tumor cells, frequent stromal reactive cells. Anti-p63, × 200.

Table

Table 1. Antibody Characteristics
 
AntibodyCloneManufacturerPretreatmentDilution
CK7OVTLNOVOCASTRAHIER-99 °C in Dako Target Retrieval solution, pH 61/50
p63-DAKOHIER-99 °C in Dako Target Retrieval solution, pH 61/50
E-cadherinNCH-38DAKOHIER-99 °C in Dako Target Retrieval solution, pH 6RTU
Mamaglobin304-IA5DAKOHIER-99 °C in Dako Target Retrieval solution, pH 61/100
ER1D5DAKOHIER-99 °C in Dako Target Retrieval solution, pH 61/50