| Journal of Medical Cases, ISSN 1923-4155 print, 1923-4163 online, Open Access |
| Article copyright, the authors; Journal compilation copyright, J Med Cases and Elmer Press Inc |
| Journal website http://www.journalmc.org |
Case Report
Volume 6, Number 4, April 2015, pages 176-178
Acebutolol and Immediate Release Melatonin in Treatment of Smith-Magenis Syndrome
Table
| Outcome measure | Acebutolol/melatonin | Acebutolol/placebo | Placebo/melatonin | Placebo/placebo |
|---|---|---|---|---|
| *P-value < 0.05. Continuous variables tested using ANOVA. Ordinal variables tested using Kruskal-Wallis. | ||||
| Sleep after pm medication (h), mean (95% CI) | 8.33 (8.06 - 8.61) | 6.49 (4.11 - 8.86) | 7.67 (5.98 - 9.35) | 7.46 (5.65 - 9.26) |
| Nocturnal sleep (h), mean (95% CI) | 8.33 (8.06 - 8.61) | 7.82 (7.26 - 8.38) | 8.37 (7.65 - 9.10) | 8.44 (7.79 - 9.10) |
| Sleep during day (h), mean (95% CI) | 1.92 (0.87 - 2.97) | 1.28 (1.01 - 1.54) | 1.44 (0.85 - 2.04) | 2.18 (1.40 - 2.95) |
| Total sleep (h), mean (95% CI)* | 10.25 (9.40 - 11.11) | 9.10 (8.69 - 9.51) | 9.82 (8.87 - 10.77) | 10.62 (9.88 - 11.36) |
| Time to sleep onset (min), mean (95% CI) | 29.17 (14.92 - 43.41) | 45.83 (13.59 - 78.08) | 30 (17.15 - 42.85) | 27 (-9.88 - 63.88) |
| Number of arousals, median (range) | 1 (1 - 1) | 1 (1 - 2) | 1 (1 - 2) | 1 (1 - 2) |
| Daytime behavior, median (range) | 1 (1 - 2) | 1.5 (1 - 3) | 2 (1 - 2) | 1.5 (1 - 2) |
| Paternal sleep score, median (range) | 3 (2 - 3) | 3 (3 - 4) | 3 (3 - 3) | 3 (2 - 3) |
| Maternal sleep score, median (range) | 4 (3 - 5) | 4 (3 - 4) | 4 (3 - 4) | 3.5 (3 - 4) |
| Global score, median (range) | 3 (3 - 4) | 3 (2 - 4) | 3 (3 - 3) | 3 (3 - 3) |