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Resection of a Huge Fourth-Recurrence Retroperitoneal Liposarcoma

Yong Zhou^a, Fu Yu Li^{a, b}, Ri Hua Xu^a, Yong Qiong Zhang^a, Hong Liu^a, Ting Jiang^a, Wen Li^a
 

^aDepartment of Hepatobiliary Surgery, West China Hospital of Sichuan University, Chengdu, China

^bCorresponding author: Fu Yu Li, Department of Hepatobiliary Surgery, West China Hospital of Sichuan University, Chengdu 610041, Sichuan Province, China. Email: lfy_74@vip.163.com

 

Manuscript accepted for publication March 23, 2012

Short title: Resection of Retroperitoneal Liposarcoma

doi:10.4021/jmc630e

 

Abstract

Resection of retroperitoneal liposarcomas continues to be a challenge for the surgeon, in particular given their large size and involvement of vital organs. We present our experience about the resection of huge fourth-recurrence retroperitoneal liposarcomas, this dumbbell-shaped mass occupied portovena-caval gap, encapsulated the portal vein and was closed attached to inferior vena cava. It was almost impossible to push the whole mass to any side for en block resection because both left and right part of this mass all reached 20 cm. So we decided to firstly resect the right part of dumbbell-shaped mass, dissect the link part from behind the portal vein, followed by pushing it to the left side and then resect together with the left part. This method made the complete resection easier and safer, of which avoid the occurrence of uncontrollable massive hemorrhage.
 

Keywords: Retroperitoneal liposarcomas; Surgery; Recurrence

 

Introduction 

Liposarcomas are rare cancers that account for approximately 15% of adult soft-tissue tumors. It should be specially stressed here that liposarcoma originate from the mesenchymal tissue and not from the fatty tissue. Retroperitoneal liposarcoma is the most common case that represents 40% of all soft tissue sarcomas occur in the retroperitoneum [1, 2].The retroperitoneal space contains, embedded in a meshwork of loose connective tissue, the adrenal glands, kidneys, and ureters; the aorta and its branches; the inferior vena cava and its tributaries; and numerous lymph nodes. This potentially large space allows the tumor to grow silently before clinical signs and symptoms appear. It has been reported that 20% of the tumors are > 10 cm at the time of diagnosis. Due to the large retroperitoneal space, patients with retroperitoneal liposarcoma have no obvious symptoms in the early stages until the mass develops enough to press or invade the neighboring structures. This late-diagnosis character therefore reduces the rate of complete resection. Even worse, RI has a high local recurrence rates compared with the liposarcomas occur in other part [3, 4]. According to a 72 cases report from Neuhaus, local recurrence rate could be as high as 65% [5], while the recurrence rate for differentiated RI in the Singer’s report even reached 83% [6]. Our recent experience with one case of fourth recurrence RI has prompted us to report the surgical management of this huge dumbbell-shaped tumor that occupied portovena gap, encapsulated the portal vein and was closed attached to inferior vena cava. 
 

Case Report 

From May 2000 and April 2009, this 40-year-old woman has surveyed four-times tumor resections including her left kidney due to the recurrence of retroperitoneal liposarcoma in the outer court. After this admission, her MRI showed that a huge middle-upper retroperitoneal mass occupied hepatorenal recess, hepatogastric ligament, hepatoduodenal ligament, the gap between the portal vein and the inferior vena cava; the mass’s upper pole reached the first portal hepatis; right bottom reached the fourth lumbar flanges, oppressed and displaced the portal vein and inferior vena cava and mesenteric root. Intraoperative foundation showed that this dumbbell-shaped mass had the integrated encapsulate in its most part, except that portion of mass had no obvious coating for the existence of scar and dense adhesion with the surrounding tissue due to prior operations (Fig. 1). The right upper part of this dumbbell-shaped mass was about 20 cm x 15 cm in size, encapsulated the portal vein and was densely attached to inferior vena cava. The left part of this mass located in hepatogastric ligament and was about 20 cm x 10 cm in size. Unfortunately, the link part of this dumbbell mass occupied the whole gap between the portal vein and inferior vena cava. Except for this, there are 8 cm part of this mass that was closely adhered to portal vein and inferior vena cava.
 

Figure 1. Her MRI revealed a dumbbell-shaped retroperitoneal liposarcomas occupied the gap between the portal vein and the inferior vena cava, encapsulated the portal vein and densely adherent to inferior vena cava.

For these reasons, the en block resection seem extremely difficulty, there would be a greater probability of uncontrollable massive hemorrhage if we perform an en block resection of this dumbbell-shaped tumor by force. Thus we decided to firstly resect its right part and found that the right-side attachment with inferior vena cava was only the close adhesion instead of the involvement. After careful dissection, the right part of mass was removed from right-side of portal vein and inferior vena cava (Fig. 2). Then we now have good vision and turn to the careful dissection of the link part of this dumbbell mass from behind portal vein. Subsequently, the left part of mass was fully mobilized from left lobe of liver and gastric lesser curvature. After finishing these steps, the link part located behind portal vein could be whole pushed to left side of hepatoduodenal ligament and thus enable the successful enblock resection together with the left part. Finally, the surrounding adipose and tissue were thoroughly cleared. Intraoperative bleeding was about 1500 mL, and her postoperative recovery was smooth. Postoperative pathologic diagnosis was liposarcoma accompanied by dedifferentiate and S - 100 (+), CD34 (+), CD117 (-). 
 

Figure 2. After careful dissection, the right part of this dumbbell-shaped was freed from the adjacent viscera and inferior vena cava.

Discussion 

Liposarcoma belongs to a kind of soft tissue sarcomas, accounting for malignant sarcomas 1%. Most of retroperitoneal liposarcoma (RI) have a complete coating and show the dilatability growth mode and low invasive capability; hence most of them can be complete resection. So far, surgery is still the only way to that RI, which emphasizes the complete surgical resection [7, 8]. The thoroughness and integrity of first excision is pivotal factor to determine its curative effect. Most of literatures agreed that the surrounding fat tissue should be thoroughly cleared, because any traces of surrounding adipose tissue are likely to conceal the variably-sized satellite focal or tumor cell. Additionally, the encapsulate of RI is actually a pseudocapsule formed by the surrounding connective tissue and tumor cells, so tumor cells often invade the pseudocapsule or surrounding tissue and even led to appearance of the skip spread. For these reasons, RI excision should include the surrounding normal tissues and involved organ [9, 10]. Due to the quick growth of tumor, neighboring large blood vessels and viscera were prone to be oppressed or even invaded. Once the invasion happens, the combined resection of multiorgan or part of the viscera is recommended on the condition of patients’ tolerance, so as to achieve the radical resection [11, 12]. According to 40 radical resections of RI from Serio’s report, 62% patients (25 cases) had to surfer the combined resection of the surrounding viscera, while major vascular resection had to be performed in another 17 cases [13]. Complete resection can not only enhance the patient’s survival time, but also reduce tumor recurrence rates. Relative studies indicated that the 5-year survival rate of complete excision and non-complete excision was respectively 75% and 34%, of which emphasizes the importance the radical resection [6, 14]. 

The specialty of this case lies in: this patient needed a reoperation for the fifth recurrence, part of mass had no obvious capsule for the prior operations’ scar and dense adhesion, a consequence of which increased the resection difficulty; more specifically, the link part of this dumbbell mass occupied the whole gap between the portal vein and the inferior vena cava, and encapsulated the portal vein; except for this, there was 8 cm part of this mass that was closely attached to portal vein and inferior vena cava; the diameter of both left and right part of this mass all reached 20 cm. For these reasons, it is almost impossible to push the whole mass to any side for en block resection. If we perform an en block resection of this dumbbell-shaped tumor by force, there would be a greater probability of uncontrollable massive hemorrhage. For this kind of dumbbell RI adjacent to major vessels, we should consider firstly resecting part of mass, pushing the rest part to the other side and then resecting together, of which make the complete resection more easy and safe. Finally, the clear of surrounding adipose and tissue must be performed so as to ensure maximum degree of the thoroughness and integrity excision, and to avoid the post-operation relapse [5, 9, 14]. 

The Current difficulty of RI treatment is high postoperative local-recurrence rate. The characteristic of RI recurrence is in situ and multiple recurrences, while distant metastases seldom occur [15, 16]. Some studies even believed that local recurrence rate of RI were still high after radical resection. According to the 72 cases report from Neuhaus, the 3-year recurrence rate after complete resection still reached 65.3%. Wang’s report agreed this point with a 65% of 3-year recurrence rate. Singer’s study indicated the positive margin and organization subtypes (especially for dedifferentiate type) were closely related to local recurrence, and were important prognostic factors affecting survival; the 3- year local recurrence rate of dedifferentiate liposarcoma as in this case could be as high as 83% [5-8, 11, 17]. At present, most of scholars think the reason of recurrence lies in the following four respects: (1) the large size tumor often invade surrounding viscera or encapsulate the major vessels, which bring difficult to obtain a negative pathology margin even with the multiorgan or vascular resection; (2) Of note, RI actually do not have a real capsule. The expansile growth mode of RI can push surrounding normal tissues to form "pseudocapsule", which make the complete resection more difficult; (3) the infiltrated growth of worse pathology subtypes also bring difficulty to the thorough removed; (4) there are many sizes of "satellite lesions” hiding around primary tumors , and these satellite lesions cannot be easily recognized under naked eyes, and are easy to be slip through net, leading to the unthrough resection [2, 3, 18, 19]. For these reasons, some scholars like Zhang et al even considered that the recurrence are impossible to be avoided even using the multiorgan resection in order to meet with the resection scope [20]. Our personal experience agreed that those recurrent cases should better be earlier detected and resected, even the palliative resection as "dissect within the capsule", also can help reduce the tumor burden and prolong survival time [21]. For those unresectable tumors, Serio et al [13] advocated the first using of chemotherapy or radiation therapy followed by surgery, so as to strive for the chance of complete or partial resection and thus improving survival. The author thinks that, although RI is characterized by high local recurrence, we should not easily give up the chance of reoperation because the pathology of those multiple recurrence cases is usually well differentiation type. Supportive of this idea came from recent literatures indicated that survival time of fourth or more resection for this kind of well-differentiation liposarcoma had no obvious difference with that of second resection [2-6, 20]. As for the using of chemoradiation, it remains controversial. Stoeckle et al believed postoperative radiotherapy could reduce local recurrence rate, the combination of surgery and radiation therapy should be the most satisfactory choice. However, some scholars disagreed with this point and suspected the actual effectiveness of chemoradiation on recurrent RI till now [18, 21]. 

In brief, RI overall survival depends on the improvement of early detection and surgical resection which emphasize the importance of radical resection. On the primes of no postoperative complications, the surrounding fat and normal tissues should be cleaned as through as possible. Relapse is pivotal factor to affect its curative effect, however, the actively treatment should be adapted to those recurrent and metastatic RI so as to prolong survival time [5-8, 11-14, 22]. 
 

Conflict of Interest

 

All authors declare that they have no conflict of interest.